CDK5R2

Protein-coding gene in the species Homo sapiens
CDK5R2
Identifiers
AliasesCDK5R2, NCK5AI, P39, p39nck5ai, cyclin-dependent kinase 5, regulatory subunit 2 (p39), cyclin dependent kinase 5 regulatory subunit 2
External IDsOMIM: 603764; MGI: 1330828; HomoloGene: 2924; GeneCards: CDK5R2; OMA:CDK5R2 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CDK5R2
Genomic location for CDK5R2
Band2q35Start218,959,666 bp[1]
End218,962,155 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CDK5R2
Genomic location for CDK5R2
Band1|1 C4Start74,894,093 bp[2]
End74,896,891 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • Brodmann area 9

  • right frontal lobe

  • putamen

  • nucleus accumbens

  • cingulate gyrus

  • anterior cingulate cortex

  • lateral nuclear group of thalamus

  • caudate nucleus

  • pituitary gland
Top expressed in
  • superior frontal gyrus

  • neural layer of retina

  • supraoptic nucleus

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • prefrontal cortex

  • cerebellar cortex

  • lateral septal nucleus

  • olfactory tubercle

  • hippocampus proper
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • cyclin-dependent protein serine/threonine kinase activator activity
  • lipid binding
  • actin binding
Cellular component
  • cytoplasm
  • protein kinase 5 complex
  • plasma membrane
  • membrane
  • growth cone
  • neuron projection
Biological process
  • positive regulation of protein kinase activity
  • regulation of cyclin-dependent protein serine/threonine kinase activity
  • neuron migration
  • hippocampus development
  • layer formation in cerebral cortex
  • cerebellum development
  • positive regulation of protein serine/threonine kinase activity
  • superior olivary nucleus maturation
  • positive regulation of calcium ion-dependent exocytosis
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8941

12570

Ensembl

ENSG00000171450

ENSMUSG00000090071

UniProt

Q13319

O35926

RefSeq (mRNA)

NM_003936

NM_009872

RefSeq (protein)

NP_003927

NP_034002

Location (UCSC)Chr 2: 218.96 – 218.96 MbChr 1: 74.89 – 74.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene.[5][6]

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase-activating proteins.[6]

Interactions

CDK5R2 has been shown to interact with Actinin, alpha 1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171450 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090071 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH (November 1995). "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator". The Journal of Biological Chemistry. 270 (45): 26897–903. doi:10.1074/jbc.270.45.26897. PMID 7592934.
  6. ^ a b "Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)".
  7. ^ Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". The Journal of Neuroscience. 22 (18): 7879–91. doi:10.1523/JNEUROSCI.22-18-07879.2002. PMC 6758084. PMID 12223541.

طراحی سایت فروشگاهی

External links

Further reading

  • Humbert S, Dhavan R, Tsai L (March 2000). "p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton". Journal of Cell Science. 113 (6): 975–83. doi:10.1242/jcs.113.6.975. PMID 10683146.
  • Humbert S, Lanier LM, Tsai LH (July 2000). "Synaptic localization of p39, a neuronal activator of cdk5". NeuroReport. 11 (10): 2213–6. doi:10.1097/00001756-200007140-00030. PMID 10923673. S2CID 24971519.
  • Muravenko OV, Gizatullin RZ, Protopopov AI, Kashuba VI, Zabarovsky ER, Zelenin AV (2000). "Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization". Cytogenetics and Cell Genetics. 89 (3–4): 160–1. doi:10.1159/000015602. PMID 10965112. S2CID 83701584.
  • Agarwal-Mawal A, Paudel HK (June 2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2". The Journal of Biological Chemistry. 276 (26): 23712–8. doi:10.1074/jbc.M010002200. PMID 11320080.
  • Patzke H, Tsai LH (March 2002). "Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29". The Journal of Biological Chemistry. 277 (10): 8054–60. doi:10.1074/jbc.M109645200. PMID 11784720.
  • Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". The Journal of Neuroscience. 22 (18): 7879–91. doi:10.1523/JNEUROSCI.22-18-07879.2002. PMC 6758084. PMID 12223541.
  • Sakashita G, Shima H, Komatsu M, Urano T, Kikuchi A, Kikuchi K (February 2003). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". Journal of Biochemistry. 133 (2): 165–71. doi:10.1093/jb/mvg020. PMID 12761178.
  • Rademakers R, Sleegers K, Theuns J, Van den Broeck M, Bel Kacem S, Nilsson LG, Adolfsson R, van Duijn CM, Van Broeckhoven C, Cruts M (2005). "Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease". Neurobiology of Aging. 26 (8): 1145–51. doi:10.1016/j.neurobiolaging.2004.10.003. PMID 15917097. S2CID 25396010.


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