DUSP22

Protein-coding gene in the species Homo sapiens
DUSP22
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WRM, 4WOH

Identifiers
AliasesDUSP22, JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX, dual specificity phosphatase 22
External IDsOMIM: 616778; MGI: 1915926; HomoloGene: 86039; GeneCards: DUSP22; OMA:DUSP22 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for DUSP22
Genomic location for DUSP22
Band6p25.3Start291,630 bp[1]
End351,355 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for DUSP22
Genomic location for DUSP22
Band13|13 A3.2Start30,843,982 bp[2]
End30,895,214 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • gingival epithelium

  • hair follicle

  • visceral pleura

  • monocyte

  • gonad

  • parietal pleura

  • Brodmann area 23

  • tibia

  • endothelial cell
Top expressed in
  • lip

  • esophagus

  • spermatid

  • skin of external ear

  • digastric muscle

  • cumulus cell

  • cornea

  • skeletal muscle tissue

  • thoracic diaphragm

  • extraocular muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein tyrosine phosphatase activity
  • phosphatase activity
  • phosphoprotein phosphatase activity
  • hydrolase activity
  • protein tyrosine/serine/threonine phosphatase activity
  • non-membrane spanning protein tyrosine phosphatase activity
  • protein tyrosine kinase binding
Cellular component
  • cytoplasm
  • nucleus
  • cytosol
  • plasma membrane
  • filamentous actin
  • leading edge of lamellipodium
Biological process
  • multicellular organism development
  • negative regulation of T cell mediated immunity
  • protein dephosphorylation
  • peptidyl-tyrosine dephosphorylation
  • cell population proliferation
  • negative regulation of T cell activation
  • negative regulation of transcription by RNA polymerase II
  • transforming growth factor beta receptor signaling pathway
  • regulation of cell population proliferation
  • positive regulation of JNK cascade
  • negative regulation of T cell receptor signaling pathway
  • dephosphorylation
  • apoptotic process
  • negative regulation of cell migration
  • negative regulation of focal adhesion assembly
  • cellular response to epidermal growth factor stimulus
  • negative regulation of non-membrane spanning protein tyrosine kinase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56940

105352

Ensembl

ENSG00000112679

ENSMUSG00000069255

UniProt

Q9NRW4

Q99N11

RefSeq (mRNA)

NM_001286555
NM_020185

NM_001037955
NM_134068

RefSeq (protein)

NP_001273484
NP_064570

NP_001033044
NP_598829

Location (UCSC)Chr 6: 0.29 – 0.35 MbChr 13: 30.84 – 30.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112679 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069255 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (Sep 1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics. 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128.
  6. ^ Shen Y, Luche R, Wei B, Gordon ML, Diltz CD, Tonks NK (Nov 2001). "Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1". Proc Natl Acad Sci U S A. 98 (24): 13613–8. Bibcode:2001PNAS...9813613S. doi:10.1073/pnas.231499098. PMC 61089. PMID 11717427.
  7. ^ "Entrez Gene: DUSP22 dual specificity phosphatase 22".

Further reading

  • Alonso A, Merlo JJ, Na S, et al. (2002). "Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR)". J. Biol. Chem. 277 (7): 5524–8. doi:10.1074/jbc.M107653200. PMID 11733513.
  • Chen AJ, Zhou G, Juan T, et al. (2002). "The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway". J. Biol. Chem. 277 (39): 36592–601. doi:10.1074/jbc.M200453200. PMID 12138158.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Alonso A, Narisawa S, Bogetz J, et al. (2004). "VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX". J. Biol. Chem. 279 (31): 32586–91. doi:10.1074/jbc.M403442200. PMID 15138252.
  • Fortna A, Kim Y, MacLaren E, et al. (2004). "Lineage-specific gene duplication and loss in human and great ape evolution". PLOS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yokota T, Nara Y, Kashima A, et al. (2007). "Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution". Proteins. 66 (2): 272–8. doi:10.1002/prot.21152. PMID 17068812. S2CID 26785784.
  • Sekine Y, Ikeda O, Hayakawa Y, et al. (2007). "DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118". Oncogene. 26 (41): 6038–49. doi:10.1038/sj.onc.1210426. hdl:2115/33065. PMID 17384676.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 22


  • v
  • t
  • e
  • 1wrm: Crystal structure of JSP-1
    1wrm: Crystal structure of JSP-1
  • v
  • t
  • e
Class I
Classical PTPs
Receptor type PTPs
Non receptor type PTPs
VH1-like or
dual specific
phosphatases
(DSPs)
MAPK phosphatases (MKPs)
Slingshots
PRLs
CDC14s
Atypical DSPs
Phosphatase and tensin
homologs (PTENs)
Myotubularins
Class II
Class III
Class IV


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