Daz interacting zinc finger protein 3

Protein-coding gene in the species Homo sapiens
DZIP3
Identifiers
AliasesDZIP3, PPP1R66, UURF2, hRUL138, DAZ interacting zinc finger protein 3
External IDsOMIM: 608672; MGI: 1917433; HomoloGene: 8771; GeneCards: DZIP3; OMA:DZIP3 - orthologs
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[1]
Chromosome 16 (mouse)
Genomic location for DZIP3
Genomic location for DZIP3
Band16|16 B5Start48,744,595 bp[1]
End48,814,528 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • Brodmann area 23

  • sperm

  • Achilles tendon

  • middle temporal gyrus

  • right uterine tube

  • superior frontal gyrus

  • postcentral gyrus

  • entorhinal cortex

  • tibia
Top expressed in
  • superior cervical ganglion

  • hand

  • ventromedial nucleus

  • Rostral migratory stream

  • arcuate nucleus

  • mammillary body

  • paraventricular nucleus of hypothalamus

  • lateral hypothalamus

  • dorsomedial hypothalamic nucleus

  • lateral septal nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • phosphatase binding
  • polyubiquitin modification-dependent protein binding
  • protein binding
  • metal ion binding
  • RNA binding
  • ubiquitin-protein transferase activity
  • transferase activity
  • unfolded protein binding
  • ubiquitin protein ligase activity
  • ubiquitin-specific protease binding
Cellular component
  • cytoplasm
  • Hrd1p ubiquitin ligase complex
  • Derlin-1 retrotranslocation complex
  • endoplasmic reticulum quality control compartment
Biological process
  • protein polyubiquitination
  • protein ubiquitination
  • ubiquitin-dependent ERAD pathway
  • endoplasmic reticulum unfolded protein response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9666

224170

Ensembl

n/a

ENSMUSG00000064061

UniProt

Q86Y13

Q7TPV2

RefSeq (mRNA)

NM_014648

NM_001110017
NM_027341
NM_001356425

RefSeq (protein)

NP_055463

NP_001103487
NP_081617
NP_001343354

Location (UCSC)n/aChr 16: 48.74 – 48.81 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase DZIP3 is a protein that in humans is encoded by the DZIP3 gene. [4]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064061 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Entrez Gene: DAZ interacting zinc finger protein 3". Retrieved 2016-05-31.

Further reading

  • Zhou W, Zhu P, Wang J, Pascual G, Ohgi KA, Lozach J, Glass CK, Rosenfeld MG (2008). "Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation". Mol. Cell. 29 (1): 69–80. doi:10.1016/j.molcel.2007.11.002. PMC 2327256. PMID 18206970.


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