Deleted in lung and esophageal cancer 1

Protein-coding gene in the species Homo sapiens

DLEC1

Identifiers

Aliases

DLEC1, CFAP81, DLC1, F56, DLC-1, deleted in lung and esophageal cancer 1, cilia and flagella associated protein, DLEC1 cilia and flagella associated protein, FAP81

External IDs

OMIM: 604050; MGI: 2443671; HomoloGene: 84733; GeneCards: DLEC1; OMA:DLEC1 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p22.2	Start	38,039,205 bp^[1]
Band	3p22.2	End	38,124,025 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 F3	Start	118,931,546 bp^[2]
Band	9\|9 F3	End	118,977,314 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

epithelium of bronchus

bronchial epithelial cell

olfactory zone of nasal mucosa

mucosa of paranasal sinus

nasal epithelium

left testis

right testis

caput epididymis

epithelium of nasopharynx

Top expressed in

spermatid

renal cortex

spermatocyte

testicle

proximal tubule

human kidney

right kidney

ovary

hypothalamus

zygote

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	molecular function
Cellular component	cytoplasm cytosol
Biological process	negative regulation of cell population proliferation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9940


320256

Ensembl


ENSG00000008226


ENSMUSG00000038060

UniProt


Q9Y238 Q32W76


Q8BLA1

RefSeq (mRNA)


NM_007335 NM_007336 NM_007337 NM_007338 NM_001321153


NM_177117 NM_001368820 NM_001368821

RefSeq (protein)


NP_001308082 NP_031361 NP_031363


n/a

Location (UCSC)

Chr 3: 38.04 – 38.12 Mb

Chr 9: 118.93 – 118.98 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Deleted in lung and esophageal cancer 1 is a protein that in humans is encoded by the DLEC1 gene. ^[5]

Function

The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000008226 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038060 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Deleted in lung and esophageal cancer 1". Retrieved 2018-04-05.

Kwong J, Lee JY, Wong KK, Zhou X, Wong DT, Lo KW, Welch WR, Berkowitz RS, Mok SC (April 2006). "Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer". Neoplasia. 8 (4): 268–78. doi:10.1593/neo.05502. PMC 1600675. PMID 16756719.
Kwong J, Chow LS, Wong AY, Hung WK, Chung GT, To KF, Chan FL, Daigo Y, Nakamura Y, Huang DP, Lo KW (February 2007). "Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma". Genes Chromosomes Cancer. 46 (2): 171–80. doi:10.1002/gcc.20398. PMID 17099870. S2CID 45238991.
Qiu GH, Salto-Tellez M, Ross JA, Yeo W, Cui Y, Wheelhouse N, Chen GG, Harrison D, Lai P, Tao Q, Hooi SC (March 2008). "The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle". J. Hepatol. 48 (3): 433–41. doi:10.1016/j.jhep.2007.11.015. PMID 18191269.
Seng TJ, Currey N, Cooper WA, Lee CS, Chan C, Horvath L, Sutherland RL, Kennedy C, McCaughan B, Kohonen-Corish MR (July 2008). "DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma". Br. J. Cancer. 99 (2): 375–82. doi:10.1038/sj.bjc.6604452. PMC 2480971. PMID 18594535.
Ying J, Poon FF, Yu J, Geng H, Wong AH, Qiu GH, Goh HK, Rha SY, Tian L, Chan AT, Sung JJ, Tao Q (February 2009). "DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers". Br. J. Cancer. 100 (4): 663–9. doi:10.1038/sj.bjc.6604888. PMC 2653732. PMID 19156137.
Canova C, Hashibe M, Simonato L, Nelis M, Metspalu A, Lagiou P, Trichopoulos D, Ahrens W, Pigeot I, Merletti F, Richiardi L, Talamini R, Barzan L, Macfarlane GJ, Macfarlane TV, Holcátová I, Bencko V, Benhamou S, Bouchardy C, Kjaerheim K, Lowry R, Agudo A, Castellsagué X, Conway DI, McKinney PA, Znaor A, McCartan BE, Healy CM, Marron M, Brennan P (April 2009). "Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project" (PDF). Cancer Res. 69 (7): 2956–65. doi:10.1158/0008-5472.CAN-08-2604. hdl:2318/104855. PMID 19339270.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Al Sarakbi W, Reefy S, Jiang WG, Roberts T, Newbold RF, Mokbel K (April 2010). "Evidence of a tumour suppressor function for DLEC1 in human breast cancer". Anticancer Res. 30 (4): 1079–82. PMID 20530412.
Zhang Y, Miao Y, Yi J, Wang R, Chen L (July 2010). "Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in non-small-cell lung cancer". Clin Lung Cancer. 11 (4): 264–70. doi:10.3816/CLC.2010.n.034. PMID 20630829.