LMLN

Protein-coding gene in the species Homo sapiens
LMLN
Identifiers
AliasesLMLN, GP63, INV, IX14, MSP, leishmanolysin like peptidase, LMNL1
External IDsOMIM: 609380; MGI: 2444736; HomoloGene: 13198; GeneCards: LMLN; OMA:LMLN - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for LMLN
Genomic location for LMLN
Band3q29Start197,960,200 bp[1]
End198,043,720 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for LMLN
Genomic location for LMLN
Band16|16 B3Start32,882,891 bp[2]
End32,948,065 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • corpus epididymis

  • secondary oocyte

  • caput epididymis

  • mucosa of paranasal sinus

  • Brodmann area 23

  • tail of epididymis

  • pancreatic ductal cell

  • sperm

  • middle temporal gyrus
Top expressed in
  • otolith organ

  • utricle

  • neural layer of retina

  • substantia nigra

  • spermatocyte

  • trigeminal ganglion

  • Rostral migratory stream

  • ventromedial nucleus

  • cumulus cell

  • retinal pigment epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • peptidase activity
  • metalloendopeptidase activity
  • hydrolase activity
  • metallopeptidase activity
  • metal ion binding
Cellular component
  • lipid droplet
  • membrane
  • focal adhesion
  • cytoplasm
  • cytosol
Biological process
  • cell cycle
  • cell adhesion
  • proteolysis
  • cell division
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

89782

239833

Ensembl

ENSG00000185621

ENSMUSG00000022802

UniProt

Q96KR4

Q8BMN4

RefSeq (mRNA)

NM_001136049
NM_033029

NM_172823

RefSeq (protein)

NP_001129521
NP_149018

NP_766411

Location (UCSC)Chr 3: 197.96 – 198.04 MbChr 16: 32.88 – 32.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leishmanolysin-like (metallopeptidase M8 family) is a protein that in humans is encoded by the LMLN gene.[5]

Function

This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185621 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022802 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Leishmanolysin-like (metallopeptidase M8 family)".

Further reading

  • Cobbe N, Marshall KM, Gururaja Rao S, Chang CW, Di Cara F, Duca E, Vass S, Kassan A, Heck MM (September 2009). "The conserved metalloprotease invadolysin localizes to the surface of lipid droplets". Journal of Cell Science. 122 (Pt 18): 3414–23. doi:10.1242/jcs.044610. PMC 2736869. PMID 19706689.
  • McHugh B, Krause SA, Yu B, Deans AM, Heasman S, McLaughlin P, Heck MM (November 2004). "Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration". The Journal of Cell Biology. 167 (4): 673–86. doi:10.1083/jcb.200405155. PMC 2172566. PMID 15557119.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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