Leucine carboxyl methyltransferase 1

Protein-coding gene in the species Homo sapiens
LCMT1
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

3IEI, 3O7W, 3P71

Identifiers
AliasesLCMT1, LCMT, PPMT1, CGI-68, leucine carboxyl methyltransferase 1
External IDsOMIM: 610286; MGI: 1353593; HomoloGene: 41123; GeneCards: LCMT1; OMA:LCMT1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for LCMT1
Genomic location for LCMT1
Band16p12.1Start25,111,731 bp[1]
End25,178,231 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for LCMT1
Genomic location for LCMT1
Band7|7 F3Start122,969,007 bp[2]
End123,029,581 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • body of pancreas

  • prefrontal cortex

  • oocyte

  • nucleus accumbens

  • right frontal lobe

  • gonad

  • pons

  • Brodmann area 23

  • anterior cingulate cortex
Top expressed in
  • lacrimal gland

  • dentate gyrus of hippocampal formation granule cell

  • Region I of hippocampus proper

  • ventromedial nucleus

  • medial ganglionic eminence

  • anterior amygdaloid area

  • nucleus accumbens

  • nucleus of stria terminalis

  • dorsomedial hypothalamic nucleus

  • superior frontal gyrus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • methyltransferase activity
  • protein methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • transferase activity
  • protein binding
  • protein C-terminal carboxyl O-methyltransferase activity
  • protein C-terminal leucine carboxyl O-methyltransferase activity
Cellular component
  • cytosol
  • nucleoplasm
Biological process
  • regulation of mitotic cell cycle spindle assembly checkpoint
  • methylation
  • C-terminal protein methylation
  • regulation of glucose metabolic process
  • regulation of apoptotic process
  • negative regulation of protein-containing complex assembly
  • protein methylation
  • G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51451

30949

Ensembl

ENSG00000205629

ENSMUSG00000030763

UniProt

Q9UIC8

n/a

RefSeq (mRNA)

NM_001032391
NM_016309
NM_016015

NM_025304
NM_001355050

RefSeq (protein)

NP_001027563
NP_057393

n/a

Location (UCSC)Chr 16: 25.11 – 25.18 MbChr 7: 122.97 – 123.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leucine carboxyl methyltransferase 1 is an enzyme that in humans is encoded by the LCMT1 gene.[5][6]

Interactions

LCMT1 has been shown to interact with FXR2.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205629 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030763 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  6. ^ "Entrez Gene: LCMT1 leucine carboxyl methyltransferase 1".
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

  • Lee JA, Pallas DC (Oct 2007). "Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells". The Journal of Biological Chemistry. 282 (42): 30974–84. doi:10.1074/jbc.M704861200. PMC 3516869. PMID 17724024.
  • De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J (Dec 1999). "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue". Biochemistry. 38 (50): 16539–47. doi:10.1021/bi991646a. PMID 10600115.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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