MYO18A

Protein-coding gene in the species Homo sapiens

MYO18A

Identifiers

Aliases

MYO18A, MYSPDZ, SPR210, myosin XVIIIA, MAJN, SP-R210

External IDs

OMIM: 610067; MGI: 2667185; HomoloGene: 7977; GeneCards: MYO18A; OMA:MYO18A - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q11.2	Start	29,071,122 bp^[1]
Band	17q11.2	End	29,180,398 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 B5	Start	77,763,246 bp^[2]
Band	11\|11 B5	End	77,865,980 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gastrocnemius muscle

skeletal muscle tissue

apex of heart

muscle of thigh

sural nerve

right auricle

left ventricle

corpus callosum

right lobe of liver

epithelium of colon

Top expressed in

muscle of thigh

esophagus

triceps brachii muscle

ankle

right ventricle

temporal muscle

skeletal muscle tissue

intestinal villus

neural layer of retina

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	DNA binding nucleotide binding ADP binding actin filament binding ATPase activity protein binding ATP binding RNA binding
Cellular component	cytoplasm membrane trans-Golgi network actomyosin cytoskeleton myosin complex endoplasmic reticulum-Golgi intermediate compartment Golgi membrane Golgi apparatus cell surface
Biological process	Golgi organization Golgi vesicle budding actomyosin structure organization DNA metabolic process asymmetric Golgi ribbon formation negative regulation of apoptotic process positive regulation of protein secretion cell migration Golgi ribbon formation regulation of macrophage activation positive regulation of opsonization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


399687


360013

Ensembl


ENSG00000196535


ENSMUSG00000000631

UniProt


Q92614


Q9JMH9

RefSeq (mRNA)

NM_001346765 NM_001346766 NM_001346767 NM_001346768 NM_078471
NM_203318


NM_001291212 NM_001291213 NM_001291214 NM_001291215 NM_011586

RefSeq (protein)

NP_001333694 NP_001333695 NP_001333696 NP_001333697 NP_510880
NP_976063


NP_001278141 NP_001278142 NP_001278143 NP_001278144 NP_035716

Location (UCSC)

Chr 17: 29.07 – 29.18 Mb

Chr 11: 77.76 – 77.87 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myosin-XVIIIa is a protein that in humans is encoded by the MYO18A gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196535 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000631 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mori K, Furusawa T, Okubo T, Inoue T, Ikawa S, Yanai N, Mori KJ, Obinata M (May 2003). "Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)". J Biochem. 133 (4): 405–13. doi:10.1093/jb/mvg053. PMID 12761286.
^ "Entrez Gene: MYO18A myosin XVIIIA".

Chroneos ZC, Abdolrasulnia R, Whitsett JA, et al. (1996). "Purification of a cell-surface receptor for surfactant protein A." J. Biol. Chem. 271 (27): 16375–83. doi:10.1074/jbc.271.27.16375. PMID 8663107.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Chang NS, Mattison J, Cao H, et al. (1999). "Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity". Biochem. Biophys. Res. Commun. 253 (3): 743–9. doi:10.1006/bbrc.1998.9846. PMID 9918798.
Ji H, Zhai Q, Zhu J, et al. (2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival". Biochem. Biophys. Res. Commun. 270 (1): 267–71. doi:10.1006/bbrc.2000.2413. PMID 10733938.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Homma K, Kikuno RF, Nagase T, et al. (2004). "Alternative splice variants encoding unstable protein domains exist in the human brain". J. Mol. Biol. 343 (5): 1207–20. doi:10.1016/j.jmb.2004.09.028. PMID 15491607.
Isogawa Y, Kon T, Inoue T, et al. (2005). "The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site". Biochemistry. 44 (16): 6190–6. doi:10.1021/bi0475931. PMID 15835906.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Yang CH, Szeliga J, Jordan J, et al. (2005). "Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A". J. Biol. Chem. 280 (41): 34447–57. doi:10.1074/jbc.M505229200. PMC 1762002. PMID 16087679.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

Proteins of the cytoskeleton

Human

Microfilaments
and ABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
and MAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal: DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3