Protein-coding gene in the species Homo sapiens
MORC1 |
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Identifiers |
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Aliases | MORC1, CT33, MORC, ZCW6, MORC family CW-type zinc finger 1 |
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External IDs | OMIM: 603205; MGI: 1316740; HomoloGene: 7843; GeneCards: MORC1; OMA:MORC1 - orthologs |
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Gene location (Human) |
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![Chromosome 3 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/300px-Ideogram_human_chromosome_3.svg.png) | Chr. | Chromosome 3 (human)[1] |
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| Band | 3q13.13 | Start | 108,958,248 bp[1] |
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End | 109,118,134 bp[1] |
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Gene location (Mouse) |
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![Chromosome 16 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/2/28/Ideogram_house_mouse_chromosome_16.svg/260px-Ideogram_house_mouse_chromosome_16.svg.png) | Chr. | Chromosome 16 (mouse)[2] |
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| Band | 16 B5|16 30.75 cM | Start | 48,251,600 bp[2] |
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End | 48,451,263 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - testicle
- gonad
- right testis
- left testis
- monocyte
- duodenum
- placenta
- anterior pituitary
- hippocampus proper
- substantia nigra
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| Top expressed in | - zygote
- Gonadal ridge
- cartilage tissue
- primary oocyte
- secondary oocyte
- blastocyst
- morula
- spermatocyte
- spermatid
- Meckel's cartilage
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - zinc ion binding
- metal ion binding
| Cellular component | - nucleus
- male germ cell nucleus
| Biological process | - multicellular organism development
- cell differentiation
- spermatogenesis
- negative regulation of transposition
- regulation of gene expression, epigenetic
- DNA methylation involved in gamete generation
- DNA hypermethylation
- negative regulation of DNA-templated transcription, initiation
- behavioral fear response
- negative regulation of gene expression
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 3: 108.96 – 109.12 Mb | Chr 16: 48.25 – 48.45 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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MORC family CW-type zinc finger 1 is a protein that in humans is encoded by the MORC1 gene.[5]
Function
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000114487 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022652 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: MORC family CW-type zinc finger 1". Retrieved 2018-07-12.
Further reading
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.