Morc family cw-type zinc finger 1

Protein-coding gene in the species Homo sapiens
MORC1
Identifiers
AliasesMORC1, CT33, MORC, ZCW6, MORC family CW-type zinc finger 1
External IDsOMIM: 603205; MGI: 1316740; HomoloGene: 7843; GeneCards: MORC1; OMA:MORC1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for MORC1
Genomic location for MORC1
Band3q13.13Start108,958,248 bp[1]
End109,118,134 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for MORC1
Genomic location for MORC1
Band16 B5|16 30.75 cMStart48,251,600 bp[2]
End48,451,263 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • right testis

  • left testis

  • monocyte

  • duodenum

  • placenta

  • anterior pituitary

  • hippocampus proper

  • substantia nigra
Top expressed in
  • zygote

  • Gonadal ridge

  • cartilage tissue

  • primary oocyte

  • secondary oocyte

  • blastocyst

  • morula

  • spermatocyte

  • spermatid

  • Meckel's cartilage
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • zinc ion binding
  • metal ion binding
Cellular component
  • nucleus
  • male germ cell nucleus
Biological process
  • multicellular organism development
  • cell differentiation
  • spermatogenesis
  • negative regulation of transposition
  • regulation of gene expression, epigenetic
  • DNA methylation involved in gamete generation
  • DNA hypermethylation
  • negative regulation of DNA-templated transcription, initiation
  • behavioral fear response
  • negative regulation of gene expression
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27136

17450

Ensembl

ENSG00000114487

ENSMUSG00000022652

UniProt

Q86VD1

Q9WVL5

RefSeq (mRNA)

NM_014429

NM_010816

RefSeq (protein)

NP_055244

NP_034946

Location (UCSC)Chr 3: 108.96 – 109.12 MbChr 16: 48.25 – 48.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MORC family CW-type zinc finger 1 is a protein that in humans is encoded by the MORC1 gene.[5]

Function

This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114487 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022652 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MORC family CW-type zinc finger 1". Retrieved 2018-07-12.

Further reading

  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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