TEX11

Protein-coding gene in the species Homo sapiens
TEX11
Identifiers
AliasesTEX11, TGC1, TSGA3, SPGFX2, testis expressed 11, ZIP4, MZIP4, Spo22, ZIP4H
External IDsOMIM: 300311; MGI: 1933237; HomoloGene: 49962; GeneCards: TEX11; OMA:TEX11 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for TEX11
Genomic location for TEX11
BandXq13.1Start70,528,940 bp[1]
End70,908,711 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for TEX11
Genomic location for TEX11
BandX|X C3Start99,882,254 bp[2]
End100,103,273 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • gonad

  • body of pancreas

  • testicle

  • right testis

  • left testis

  • Epithelium of choroid plexus

  • mucosa of transverse colon

  • pancreatic epithelial cell

  • mucosa of sigmoid colon
Top expressed in
  • spermatid

  • zygote

  • secondary oocyte

  • spermatocyte

  • embryo

  • embryo

  • primary oocyte

  • seminiferous tubule

  • Gonadal ridge

  • iris
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • central element
  • condensed nuclear chromosome
  • chromosome
  • synaptonemal complex
Biological process
  • fertilization
  • chiasma assembly
  • male meiosis chromosome segregation
  • synaptonemal complex assembly
  • resolution of meiotic recombination intermediates
  • negative regulation of apoptotic process
  • meiosis
  • male meiotic nuclear division
  • male gonad development
  • meiotic gene conversion
  • reciprocal meiotic recombination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56159

83558

Ensembl

ENSG00000120498

ENSMUSG00000009670

UniProt

Q8IYF3

Q14AT2

RefSeq (mRNA)

NM_001003811
NM_031276

NM_001167997
NM_031384

RefSeq (protein)

NP_001003811
NP_112566

NP_001161469
NP_113561

Location (UCSC)Chr X: 70.53 – 70.91 MbChr X: 99.88 – 100.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Testis expressed 11 is a protein that in humans is encoded by the TEX11 gene. [5]

Function

This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120498 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009670 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Testis expressed 11". Retrieved 2018-03-03.

Further reading

  • Wang PJ, McCarrey JR, Yang F, Page DC (April 2001). "An abundance of X-linked genes expressed in spermatogonia". Nat. Genet. 27 (4): 422–6. doi:10.1038/86927. PMID 11279525. S2CID 14200121.
  • Aston KI, Krausz C, Laface I, Ruiz-Castané E, Carrell DT (June 2010). "Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent" (PDF). Hum. Reprod. 25 (6): 1383–97. doi:10.1093/humrep/deq081. PMID 20378615.
  • Yatsenko AN, Georgiadis AP, Röpke A, Berman AJ, Jaffe T, Olszewska M, Westernströer B, Sanfilippo J, Kurpisz M, Rajkovic A, Yatsenko SA, Kliesch S, Schlatt S, Tüttelmann F (May 2015). "X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men". N. Engl. J. Med. 372 (22): 2097–107. doi:10.1056/NEJMoa1406192. PMC 4470617. PMID 25970010.
  • Yang F, Silber S, Leu NA, Oates RD, Marszalek JD, Skaletsky H, Brown LG, Rozen S, Page DC, Wang PJ (September 2015). "TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse". EMBO Mol Med. 7 (9): 1198–210. doi:10.15252/emmm.201404967. PMC 4568952. PMID 26136358.
  • Yang F, Silber S, Leu NA, Oates RD, Marszalek JD, Skaletsky H, Brown LG, Rozen S, Page DC, Wang PJ (September 2015). "TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse". EMBO Mol Med. 7 (9): 1198–210. doi:10.15252/emmm.201404967. PMC 4568952. PMID 26136358.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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