TRANK1

Protein-coding gene in the species Homo sapiens
TRANK1
Identifiers
AliasesTRANK1, LBA1, tetratricopeptide repeat and ankyrin repeat containing 1
External IDsMGI: 1341834; HomoloGene: 45845; GeneCards: TRANK1; OMA:TRANK1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for TRANK1
Genomic location for TRANK1
Band3p22.2Start36,826,819 bp[1]
End36,945,057 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for TRANK1
Genomic location for TRANK1
Band9|9 F3Start111,140,807 bp[2]
End111,224,843 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • left uterine tube

  • jejunal mucosa

  • body of uterus

  • right uterine tube

  • canal of the cervix

  • blood

  • Descending thoracic aorta

  • granulocyte

  • rectum
Top expressed in
  • superior frontal gyrus

  • primary visual cortex

  • adrenal cortex

  • olfactory tubercle

  • lumbar subsegment of spinal cord

  • dentate gyrus of hippocampal formation granule cell

  • nucleus accumbens

  • piriform cortex

  • nucleus of stria terminalis

  • frenulum of tongue
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

9881

320429

Ensembl

ENSG00000168016

ENSMUSG00000062296

UniProt

O15050

Q8BV79

RefSeq (mRNA)

NM_014831
NM_001329998

NM_001164659

RefSeq (protein)

NP_001316927
NP_055646

NP_001158131

Location (UCSC)Chr 3: 36.83 – 36.95 MbChr 9: 111.14 – 111.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetratricopeptide repeat and ankyrin repeat containing 1 is a protein that in humans is encoded by the TRANK1 gene.[5]

Disease Linkage

Through a Genome-wide association study, TRANK1 has been relationed with the Bipolar disorder.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168016 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062296 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Tetratricopeptide repeat and ankyrin repeat containing 1".
  6. ^ Mühleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, et al. (March 2014). "Genome-wide association study reveals two new risk loci for bipolar disorder". Nature Communications. 5: 3339. Bibcode:2014NatCo...5.3339M. doi:10.1038/ncomms4339. hdl:1959.4/unsworks_13067. PMID 24618891.

Further reading

  • Goes FS, Hamshere ML, Seifuddin F, Pirooznia M, Belmonte-Mahon P, Breuer R, et al. (October 2012). "Genome-wide association of mood-incongruent psychotic bipolar disorder". Translational Psychiatry. 2 (10): e180. doi:10.1038/tp.2012.106. PMC 3565814. PMID 23092984.
  • Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, et al. (February 2013). "Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder". Molecular Psychiatry. 18 (2): 195–205. doi:10.1038/mp.2011.157. PMID 22182935.
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