PTK6
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| Proteinska tirozinska kinaza 6 | |||||||||||
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 NMR struktura SH2 domena PTK6.[1] | |||||||||||
| Dostupne strukture | |||||||||||
| 1RJA, 2KGT | |||||||||||
| Identifikatori | |||||||||||
| Simboli | PTK6; BRK | ||||||||||
| Vanjski ID | OMIM: 602004 MGI: 99683 HomoloGene: 68494 GeneCards: PTK6 Gene | ||||||||||
| EC broj | 2.7.10.2 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5753 | 20459 | |||||||||
| Ensembl | ENSG00000101213 | ENSMUSG00000038751 | |||||||||
| UniProt | Q13882 | Q64434 | |||||||||
| Ref. Sekv. (iRNK) | NM_001256358 | NM_009184 | |||||||||
| Ref. Sekv. (protein) | NP_001243287 | NP_033210 | |||||||||
| Lokacija (UCSC) | Chr 20: 62.16 - 62.17 Mb | Chr 2: 181.19 - 181.2 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Tirozinska proteinska kinaza 6 je enzim koji je kod ljudi kodiran PTK6 genom.[2][3][4]
Funkcija
Tirozinska proteinska kinazae 6 (takođe poznata kao kinaza tumora dojke, Brk) je citoplazmna nereceptorska proteinska kinaza koja deluje kao intraćelijski prenosnik signala u epitelnim tkivima. Ovaj protein je podložan autofosforilaciji.[4]
Klinički značaj
Prekomerno izražavanja ovog gena u epitelnim ćelijama sisara dovodi do senzitizacije ćelija na epidermalni faktor rasta, što dovodi do parcijalno transformisanog fenotipa. Izražavanje ovog gena je detektovano u niskim nivoima u pojedinim tumorima dojke, do čega ne dolazi u normalnom tkivu dojke.[4]
Interactions
PTK6 formira interakcije sa STAP2[5] i KHDRBS1.[6]
Reference
- ↑ PDB 1rja; Hong E, Shin J, Kim HI, Lee ST, Lee W (July 2004). „Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain”. J. Biol. Chem. 279 (28): 29700–8. DOI:10.1074/jbc.M313185200. PMID 15056653.
- ↑ Lee ST, Strunk KM, Spritz RA (December 1993). „A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes”. Oncogene 8 (12): 3403–10. PMID 8247543.
- ↑ Park SH, Lee KH, Kim H, Lee ST (September 1997). „Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization”. Cytogenet Cell Genet 77 (3–4): 271–2. DOI:10.1159/000134595. PMID 9284935.
- ↑ 4,0 4,1 4,2 „Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6”.
- ↑ Mitchell, P J; Sara E A; Crompton M R (August 2000). „A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK”. Oncogene (ENGLAND) 19 (37): 4273–82. DOI:10.1038/sj.onc.1203775. ISSN 0950-9232. PMID 10980601.
- ↑ Derry, J J; Richard S; Valderrama Carvajal H; Ye X; Vasioukhin V; Cochrane A W; Chen T; Tyner A L (August 2000). „Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability”. Mol. Cell. Biol. (UNITED STATES) 20 (16): 6114–26. DOI:10.1128/MCB.20.16.6114-6126.2000. ISSN 0270-7306. PMC 86087. PMID 10913193.
Literatura
- Serfas MS, Tyner AL (2003). „Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases”. Oncol. Res. 13 (6–10): 409–19. PMID 12725532.
- Mitchell PJ, Barker KT, Martindale JE, et al. (1994). „Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours”. Oncogene 9 (8): 2383–90. PMID 8036022.
- Kamalati T, Jolin HE, Mitchell PJ, et al. (1997). „Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor”. J. Biol. Chem. 271 (48): 30956–63. DOI:10.1074/jbc.271.48.30956. PMID 8940083.
- Lee H, Kim M, Lee KH, et al. (1998). „Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase”. Mol. Cells 8 (4): 401–7. PMID 9749526.
- Llor X, Serfas MS, Bie W, et al. (1999). „BRK/Sik expression in the gastrointestinal tract and in colon tumors”. Clin. Cancer Res. 5 (7): 1767–77. PMID 10430081.
- Derry JJ, Richard S, Valderrama Carvajal H, et al. (2000). „Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability”. Mol. Cell. Biol. 20 (16): 6114–26. DOI:10.1128/MCB.20.16.6114-6126.2000. PMC 86087. PMID 10913193.
- Mitchell PJ, Sara EA, Crompton MR (2000). „A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK”. Oncogene 19 (37): 4273–82. DOI:10.1038/sj.onc.1203775. PMID 10980601.
- Kamalati T, Jolin HE, Fry MJ, Crompton MR (2000). „Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation”. Oncogene 19 (48): 5471–6. DOI:10.1038/sj.onc.1203931. PMID 11114724.
- Hong E, Shin J, Bang E, et al. (2001). „Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain”. J. Biomol. NMR 19 (3): 291–2. DOI:10.1023/A:1011221125013. PMID 11330822.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20”. Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052.
- Kang KN, Kim M, Pae KM, Lee ST (2002). „Characterization of the 5'-flanking region of the human PTK6 gene”. Biochim. Biophys. Acta 1574 (3): 365–9. DOI:10.1016/s0167-4781(02)00234-8. PMID 11997104.
- Qiu H, Miller WT (2002). „Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition”. J. Biol. Chem. 277 (37): 34634–41. DOI:10.1074/jbc.M203877200. PMID 12121988.
- Koo BK, Kim MH, Lee ST, Lee W (2002). „Purification and spectroscopic characterization of the human protein tyrosine kinase-6 SH3 domain”. J. Biochem. Mol. Biol. 35 (3): 343–7. DOI:10.5483/BMBRep.2002.35.3.343. PMID 12297019.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Coyle JH, Guzik BW, Bor YC, et al. (2003). „Sam68 Enhances the Cytoplasmic Utilization of Intron-Containing RNA and Is Functionally Regulated by the Nuclear Kinase Sik/BRK”. Mol. Cell. Biol. 23 (1): 92–103. DOI:10.1128/MCB.23.1.92-103.2003. PMC 140664. PMID 12482964.
- Derry JJ, Prins GS, Ray V, Tyner AL (2003). „Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells”. Oncogene 22 (27): 4212–20. DOI:10.1038/sj.onc.1206465. PMID 12833144.
- Qiu H, Miller WT (2004). „Role of the Brk SH3 domain in substrate recognition”. Oncogene 23 (12): 2216–23. DOI:10.1038/sj.onc.1207339. PMID 14676834.
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