HAS1

HAS1
Identifikatori
AlijasiHAS1
Spoljašnji IDOMIM: 601463 MGI: 106590 HomoloGene: 1165 GeneCards: HAS1
Genska lokacija (miš)
Chromosome 17 (mouse)
Hr.Chromosome 17 (mouse)[1]
Chromosome 17 (mouse)
Genomska lokacija za HAS1
Genomska lokacija za HAS1
Band17 A3.2|17 10.53 cMStart18,063,585 bp[1]
Kraj18,075,467 bp[1]
Obrazac RNK izražavanja
More reference expression data
Genska ontologija
Molecular function• glycosyltransferase activity
• transferase activity
• hyaluronan synthase activity
• GO:0001948, GO:0016582 везивање за протеине плазме
• identical protein binding
Cellular component• цитоплазма
• саставни део мембране
• ћелијска мембрана
• integral component of plasma membrane
• мембрана
Biological process• Ćelijska adhezija
• negative regulation of fibroblast migration
• hyaluronan biosynthetic process
• cellular response to platelet-derived growth factor stimulus
• extracellular matrix assembly
• glycosaminoglycan biosynthetic process
• extracellular polysaccharide biosynthetic process
• estrous cycle
Sources:Amigo / QuickGO
Ortolozi
VrsteČovekMiš
Entrez

3036

15116

Ensembl

ENSG00000105509

ENSMUSG00000003665

UniProt

Q92839

Q61647

RefSeq (mRNA)

NM_001297436
NM_001523

NM_008215

RefSeq (protein)

NP_001284365
NP_001514

NP_032241

Location (UCSC)n/aChr 17: 18.06 – 18.08 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Hijaluronanska sintaza 1 je enzim koji je kod ljudi kodiran genom HAS1.[4][5]

Reference

  1. ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000003665 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (јул 1997). „Chromosomal localization of the human and mouse hyaluronan synthase genes”. Genomics. 41 (3): 493—7. PMID 9169154. doi:10.1006/geno.1997.4696. CS1 одржавање: Формат датума (веза)
  5. ^ „Entrez Gene: HAS1 hyaluronan synthase 1”. 

Literatura

  • Spicer AP, Nguyen TK (1999). „Mammalian hyaluronan synthases: investigation of functional relationships in vivo.”. Biochem. Soc. Trans. 27 (2): 109—15. PMID 10093717. doi:10.1042/bst0270109. 
  • Mian N (1987). „Analysis of cell-growth-phase-related variations in hyaluronate synthase activity of isolated plasma-membrane fractions of cultured human skin fibroblasts.”. Biochem. J. 237 (2): 333—42. PMC 1146992 Слободан приступ. PMID 3099751. doi:10.1042/bj2370333. 
  • Itano N, Kimata K (1996). „Molecular cloning of human hyaluronan synthase.”. Biochem. Biophys. Res. Commun. 222 (3): 816—20. PMID 8651928. doi:10.1006/bbrc.1996.0827. 
  • Shyjan AM, Heldin P, Butcher EC, et al. (1996). „Functional cloning of the cDNA for a human hyaluronan synthase.”. J. Biol. Chem. 271 (38): 23395—9. PMID 8798544. doi:10.1074/jbc.271.38.23395 Слободан приступ. 
  • Simpson MA, Wilson CM, Furcht LT, et al. (2002). „Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.”. J. Biol. Chem. 277 (12): 10050—7. PMID 11790779. doi:10.1074/jbc.M110069200. 
  • Calabro A, Oken MM, Hascall VC, Masellis AM (2002). „Characterization of hyaluronan synthase expression and hyaluronan synthesis in bone marrow mesenchymal progenitor cells: predominant expression of HAS1 mRNA and up-regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma patients.”. Blood. 100 (7): 2578—85. PMID 12239172. doi:10.1182/blood-2002-01-0030 Слободан приступ. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899 Слободан приступ. 
  • Adamia S, Crainie M, Kriangkum J, et al. (2003). „Abnormal expression of hyaluronan synthases in patients with Waldenstrom's macroglobulimenia.”. Semin. Oncol. 30 (2): 165—8. PMID 12720129. doi:10.1053/sonc.2003.50042. 
  • Suzuki K, Yamamoto T, Usui T, et al. (2004). „Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta.”. Jpn. J. Ophthalmol. 47 (6): 557—64. PMID 14636845. doi:10.1016/j.jjo.2003.09.001. 
  • Adamia S, Reiman T, Crainie M, et al. (2005). „Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma.”. Blood. 105 (12): 4836—44. PMC 1894997 Слободан приступ. PMID 15731173. doi:10.1182/blood-2004-10-3825. 
  • Yabushita H, Kishida T, Fusano K, et al. (2005). „Role of hyaluronan and hyaluronan synthase in endometrial cancer.”. Oncol. Rep. 13 (6): 1101—5. PMID 15870928. doi:10.3892/or.13.6.1101. 
  • Stuhlmeier KM, Pollaschek C (2006). „Adenovirus-mediated gene transfer of mutated IkappaB kinase and IkappaBalpha reveal NF-kappaB-dependent as well as NF-kappaB-independent pathways of HAS1 activation.”. J. Biol. Chem. 280 (52): 42766—73. PMID 16258173. doi:10.1074/jbc.M503374200. 
  • Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM (2006). „Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells.”. Biochim. Biophys. Acta. 1760 (6): 890—5. PMID 16564133. doi:10.1016/j.bbagen.2006.02.002. 
  • Kao JJ (2007). „The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1.”. Exp. Gerontol. 41 (6): 641—7. PMID 16723203. S2CID 54406345. doi:10.1016/j.exger.2006.04.003. 
  • Campo GM, Avenoso A, Campo S, et al. (2007). „TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate.”. Mol. Cell. Biochem. 292 (1–2): 169—78. PMID 16786194. S2CID 37598580. doi:10.1007/s11010-006-9230-7. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry.”. Mol. Syst. Biol. 3 (1): 89. PMC 1847948 Слободан приступ. PMID 17353931. doi:10.1038/msb4100134. 
  • Meran S, Thomas D, Stephens P, et al. (2007). „Involvement of hyaluronan in regulation of fibroblast phenotype.”. J. Biol. Chem. 282 (35): 25687—97. PMID 17611197. doi:10.1074/jbc.M700773200 Слободан приступ. 
  • Kyossev Z, Weigel PH (2007). „An enzyme capture assay for analysis of active hyaluronan synthases.”. Anal. Biochem. 371 (1): 62—70. PMID 17904513. doi:10.1016/j.ab.2007.08.025. 
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2.4.1: Heksozil-
transferaze
Glukozil-
Galaktozil-
Glukuronozil-
Fukozil-
Manozil-
2.4.2: Pentozil-
transferaze
Riboza
ADP-riboziltransferaza
Fosforiboziltransferaza
Drugi
Drugi
2.4.99: Sijalil
transferaze
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Teme
Tipovi
  • B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6